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Oligonucleotide Analytical Chemistry Process Development Co-op (Spring 2025)

Wave
Full-time
On-site
Lexington, Massachusetts, United States
Description

Oligonucleotide Analytical Chemistry Process Development Co-op Position


Wave Life Sciences is a biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health. Our RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation and deep insights in human genetics to deliver scientific breakthroughs that treat both rare and prevalent disorders. Our toolkit of RNA-targeting modalities includes editing, splicing, RNA interference and antisense silencing, providing us with unmatched capabilities for designing and sustainably delivering candidates that optimally address disease biology. Our diversified pipeline includes clinical programs in Duchenne muscular dystrophy, Alpha-1 antitrypsin deficiency and Huntington’s disease, as well as a preclinical program in obesity. Driven by the calling to “Reimagine Possible”, we are leading the charge toward a world in which human potential is no longer hindered by the burden of disease.



Wave Life Sciences seeks a highly motivated co-op student to join its team of scientists in Lexington, Massachusetts.  The co-op student will gain exposure to oligonucleotide synthesis, analytical methods for analysis, and formulations. Co-ops will be trained in a variety of laboratory techniques and instrumentation, making this an excellent learning opportunity.  This is an ideal position for any student, including those looking for their first co-op, with strong organizational skills and attention to detail who thrives in a team-oriented, fast-paced and cross-disciplinary biotech environment.  Analytical chemistry or biochemistry laboratory experience is preferred. 


Responsibilities



  • Prepare buffer and samples for analysis

  • Perform analytical QC of oligonucleotides by UV, endotoxin, osmolality, pH, LC, and LC-MS

  • Assist with various solubility and stability studies

  • Assist with method development activities and data analysis using a variety of software platforms

  • Assist with management of oligonucleotide inventory

  • Assist with maintenance and troubleshooting of lab equipment such as LC and LC-MS instrumentation

  • Document experiments in an electronic notebook 


Skills and Competencies



  • Strict adherence to lab safety protocols including PPE

  • Effective communication skills and ability to present experimental results within a small team